Beilstein J. Org. Chem.2017,13, 1168–1173, doi:10.3762/bjoc.13.115
engineering and evolution of these proteins for biocatalyst application.
Keywords: alkaloidbiogenesis; biosynthetic divergency; C–H activation; halogenase; non-heme iron enzyme; Introduction
Carbon–halogen (C–X) bonds are prevalent structural motifs in modern agrochemicals, pharmaceuticals and bioactive
], analogous oxidative functionalizations with halogens via C–H activations remain challenging that need to be addressed [9][10][11]. Recently, during the systematic investigation of hapalindole-type alkaloidbiogenesis [12][13][14][15][16][17][18][19], we discovered a family of Fe/2OG-dependent halogenases
PDF
Graphical Abstract
Figure 1:
Comparative analysis of hapalindole-type alkaloids and their BGCs in two welwitindolinone producers...